Plant and Microbial Biology 200B/220B
Genomics and Computational Biology

Fall 2007

Instructor: Kimmen Sjölander

Principles of computational and genomic biology. Covers evolutionary, algorithmic, and statistical foundations of sequence analysis, allowing students to understand concepts underlying modern computational methods. Practical applications will be pursued in student-coordinated sessions.

Lecture notes

Lecture 1

Intro to protein structure

Structure prediction

Evolution

MSAs, HMMs and structure prediction (again)

MreB searches

Active sites (1)

Active sites (2)

How to design experiments: Active site prediction

Assessing methods for target-template alignment